New preprint on extrapolating histone marks across contexts is available.

I’ve been thinking about how and when it is justified to use functional genomics data (e.g., histone modifications, DNA methylation, DNaseI hypersensitivity, etc.) collected in one cellular context for an analysis in a different context.  I performed a case study of this question for H3K27ac and H3K4me1 marks across developmental stages, tissues, and species. Check out the manuscript for the results:

Extrapolating histone marks across developmental stages, tissues, and species: an enhancer prediction case study [bioRxiv]