Meet the Capra Lab at SMBE 2017

Ling, Laura, David, and I will be heading to Austin this week for SMBE 2017.

I’m organizing a symposium on Tuesday on the Evolution of Gene Regulation. Ling will give a talk on Tuesday at 1:30pm on “Sequence properties of enhancers are conserved across mammals”. Laura will present her poster “Sequence characteristics distinguish enhancers from promoters” (POA-264), and¬†David will present his poster “A fly in the ointment: compensatory mutations in Drosophila gene deletion strains may confound reproducibility” (POB-123).

Stop by if you are interested!

Welcome to Souhrid Mukherjee!

We are very happy to welcome Souhrid Mukherjee as a new PhD student in our group. Souhrid will join the Biological Sciences PhD program. He is interested in integrating a systems biology perspective into our work on personalized structural biology. He has a B.S and M.S in Biochemistry, from the University of Calcutta.

Greg Sliwoski wins best talk!

Congratulations to Greg Sliwoski for winning the best presentation award for his talk “A clinic-driven pipeline for prioritizing variants of unknown significance with personalized structural biology” at the 2017 Department of Biomedical Informatics Research Forum!

Museum Exhibit on Our Work!

We collaborated with curators at the Science Museum London to develop an exhibit on how ancient DNA affects us today:

Who Am I? Update case “How can ancient DNA affect you?” Display exploring the ways that the DNA of our ancient ancestors is impacting health today

Photo credit: Science Museum Group Collection
© The Board of Trustees of the Science Museum

If you happen to be in London this spring or summer, check it out!

Catch up with us at ASHG

Alex, Corinne, Mike, and I will be attending the annual American Society for Human Genetics meeting in Vancouver this week. You’ll have plenty of chances to hear about our work. On Wednesday morning, I’ll present a talk entitled “First depleted, then enriched: The evolution of transposable element co-option into gene regulatory function” on our work to understand when and how transposable element derived sequence gain gene regulatory function.

Alex will present a poster on “Genomic context drives the conservation of enhancer activity across species” (PrmNr 2141).

Corinne will present a poster on “Leveraging large-scale clinical biobanks to study recent human evolution (PgmNr 1075)”.

Mike will present a poster on “Comprehensive analysis of the spatial distribution of missense variants in protein structures reveals patterns predictive of pathogenicity (PgmNr 1869)”.

Congratulations to Corinne and Mike for winning Reviewer’s Choice Awards, meaning that their abstracts were in the top 10% of all abstracts. Mike’s work was also selected for the Friday Poster Walk.

New Paper on Genome Stability Published!

We are very pleased that our collaboration with Nasim Sabouri’s group in Sweden in which we show that the Pfh1 DNA helicase interacts with components of replisome to maintain proper fork progression and genome stability has been published in PLOS Genetics! Check it out:

Pfh1 is an accessory replicative helicase that interacts with the replisome to facilitate fork progression and preserve genome integrity