Congratulations to Laura for publishing her first paper! If you are interested in how enhancers’ DNA sequences influence their activity take a look. Spoiler alert: patterns are different between humans and flies!
Ling, Laura, David, and I will be heading to Austin this week for SMBE 2017.
I’m organizing a symposium on Tuesday on the Evolution of Gene Regulation. Ling will give a talk on Tuesday at 1:30pm on “Sequence properties of enhancers are conserved across mammals”. Laura will present her poster “Sequence characteristics distinguish enhancers from promoters” (POA-264), and David will present his poster “A fly in the ointment: compensatory mutations in Drosophila gene deletion strains may confound reproducibility” (POB-123).
Stop by if you are interested!
We are very happy to welcome Souhrid Mukherjee as a new PhD student in our group. Souhrid will join the Biological Sciences PhD program. He is interested in integrating a systems biology perspective into our work on personalized structural biology. He has a B.S and M.S in Biochemistry, from the University of Calcutta.
Congratulations to Greg Sliwoski for winning the best presentation award for his talk “A clinic-driven pipeline for prioritizing variants of unknown significance with personalized structural biology” at the 2017 Department of Biomedical Informatics Research Forum!
Tony was recently interviewed by the New York Times about the lab’s work to understand the health legacy of interbreeding between Neanderthals and anatomically modern humans:
Alex, Corinne, Mike, and I will be attending the annual American Society for Human Genetics meeting in Vancouver this week. You’ll have plenty of chances to hear about our work. On Wednesday morning, I’ll present a talk entitled “First depleted, then enriched: The evolution of transposable element co-option into gene regulatory function” on our work to understand when and how transposable element derived sequence gain gene regulatory function.
Alex will present a poster on “Genomic context drives the conservation of enhancer activity across species” (PrmNr 2141).
Corinne will present a poster on “Leveraging large-scale clinical biobanks to study recent human evolution (PgmNr 1075)”.
Mike will present a poster on “Comprehensive analysis of the spatial distribution of missense variants in protein structures reveals patterns predictive of pathogenicity (PgmNr 1869)”.
Congratulations to Corinne and Mike for winning Reviewer’s Choice Awards, meaning that their abstracts were in the top 10% of all abstracts. Mike’s work was also selected for the Friday Poster Walk.
We are very happy that Alex’s paper evaluating the evidence for genetic interactions influencing gene expression has been published in the American Journal of Human Genetics. Check it out:
Are Interactions between cis-Regulatory Variants Evidence for Biological Epistasis or Statistical Artifacts?
We are very pleased that our collaboration with Nasim Sabouri’s group in Sweden in which we show that the Pfh1 DNA helicase interacts with components of replisome to maintain proper fork progression and genome stability has been published in PLOS Genetics! Check it out: