Congratulations to Dr. Mike Sivley on successfully defending his PhD! His dissertation is titled “Constraint on Rare Protein-Coding Variation: Pathogenicity Prediction and Phenotypic Discovery.”
Alex’s paper on how mismatches in local genetic ancestry along the genome in admixed individuals can influence associations between genetic variants and traits has just come out in the 2018 Proceedings of the Pacific Symposium on Biocomputing. In this manuscript, we develop a model that captures the effect of both single variants and local ancestry on traits of interest, and use it to identify examples where local ancestry transitions significantly interact with nearby variants to influence metabolic traits. Check it out!